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metronidazole will increase the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.fedratinib will enhance the amount or outcome of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep track of. Modify dose of drugs which might be CYP2C19 substrates as required.deferasirox